QC Profiling

Automated LC-MS Quality Control of DNA Labeling Reactions

Managing and assessing LC-MS data for DNA Encoded Libraries (DELs) is challenging, especially with expanding libraries.
QC Profiling automates analysis and quality control for DEL generation, enabling high-throughput processing and reporting of LC-MS results. It assesses DEL mixture composition, confirms desired products, and identifies impurities.

“This software easily multiplied our productivity by 3, greatly enhancing the reproducibility and drastically reducing the chance of human error”

Roberto Martinez

Senior Scientist – Novartis

QC Profiling

Benefits

Efficient evaluation of hundreds of DNA conjugate reactions without throughput limits.

Enhanced accuracy with automated deconvolution of peaks and precise mass attribution ensuring error-free results.

Consistent interpretation of the results minimizing variability between analyses and reducing mental workload.

Streamlined analyses enabling quick decision-making based on comprehensive data insights.

QC Profiling

Features

Flexible Input and Output Configuration

Flexible Input: Seamlessly incorporate and customize your input using a CSV file. Add and organize inputs into groups to generate comprehensive results for each group, ensuring efficient and structured data processing.
Customizable Output: Use default templates for reporting or create a unique layout. Customize the CSV output by including specific columns needed for comprehensive reporting, tailoring it to your requirements for improved data analysis and interpretation.

Robust and Customizable Analysis Algorithms

Streamlined Spectral Deconvolution: Efficiently deconvolute spectra and match primary components of UV peaks for accurate analysis.
Noisy Chromatogram Identification: Quickly identify and label noisy chromatograms for easy review and further action.
Accurate Purity Calculations: Exclude residual chromatogram peaks from purity calculations and identify UV peaks from low molecular weight impurities for precise results.

Quality Control tests

Precise QC Criteria: Define your quality control criteria with specific thresholds and associate distinct flag colors to each criterion. This setup ensures prompt flag generation when a quality test falls short, allowing for immediate issue identification.
Efficient Review Process: Facilitate a swift and efficient review of results to enhance productivity. The intuitive flagging system enables quick identification and assessment of quality control issues, streamlining the process of addressing and resolving discrepancies. This method improves laboratory productivity and ensures accurate and reliable results.

Streamlined Result Review and Reporting

Effortless Review: Easily review your analysis results within the Mnova interface. With Mgears and the QC Profiling Result Viewers, access and assess all critical results on a single screen.
Visual Results: Visualize results with colored charts and instantly spot control flags and warnings for efficient exception-based review.
Comment and Save: Append comments to your results and save them directly to the output CSV file.
On-the-Fly Modifications: Modify your analysis by adding or removing masses as you review the results, and launch recalculations as needed.

Help & Resources

Guides

QC Profiling - User Manual

Mnova Gears - Manual

Videos

Webinar: Semi-automated LC-MS interpretation of DNA conjugates in 96 or 384 well plates

QC Profiling

Related Applications

Identification & Quantification

Mnova-for-Identification-and-quantitation-application

QC Profiling

Automated LC-MS Quality Control of DNA Labeling Reactions

Benefits