Ligand Screening & Binding
Guides & Manuals
Mnova Screen 2D - Starting Guide
Screen 2D
Efficient Batch Processing Tools for Hit finding using Target-Observed 2D NMR
Screen 2D processes and analyzes target-observed 2D spectra (e.g., 1H-15N, 1H-13C or 1H-13C/ 15N dual heteronuclear correlation (HSQC or HMQC) of single-point binding data. It enables batch processing of multiple 2D spectra, tracks peak shifts, and ranks ligands based on the CSPs calculated.
This product is related to Mnova Screen, which processes and analyzes ligand-observed 1D NMR experiments like STD, T1rho, CPMG and WaterLogsy.
Download Mnova for a 45-Day Free Trial on Mnova Screen 2D
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marzo 7, 2024
15.0.1
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marzo 7, 2024
15.0.1
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marzo 7, 2024
15.0.1
Screen 2D
Benefits
Excellent tools for high-throughput hit identification.
Efficient “Screen 2D Viewer” tool for analysis inspection and refinement, peak by peak.
Huge time savings by batch processing large numbers of 2D spectra with the same processing parameters to gain consistent results.
High efficiency and accuracy in automated peak picking, matching, tracking for computing CSPs and ligan ranking.
Screen 2D
Features
- Batch processes and analyzes protein-ligand screening spectra for multiple ligands.
- Automatically identifies and matches peaks in Reference and Test spectra, calculating CSP for each peak.
- Applies statistical analysis to CSP values, reporting Mean CSP, Max CSP, and CSP Scores.
- Classifies ligands by CSP Scores, correlating levels with ligand-protein affinity.
- Autocategorizes ligands as hits or aggregators based on CSP Scores and user-defined thresholds.
Screen 2D
Videos
Help & Resources
Mnova Screen 2D - Starting Guide
Screen 2D
Related Applications
Academic, Government & Industrial
Target Audience
Medicinal Chemists
Analytical Chemists
Biochemists
Screen 2D
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