Ligand Screening & Binding

What can Mnova do for your ligand and binding screening?

High-Throughput Ligand Screening by 1D NMR

Supporting various experiments including ¹H or ¹⁹F, single compounds or mixtures, and multiple types of spectra (STD, T1rho, WaterLogsy, CPMG), Mnova Screen ensures efficient data handling and reporting. This tool already used by top pharmaceutical companies, is designed for ligand screening NMR data.

Mnova-for-Ligand-binding-screening-applications

Advanced 2D NMR Screening

Enhancing lead discovery through efficient batch processing, Mnova 2D Screen identifies binding ligands based on chemical shift perturbations, Mnova Screen 2D processes protein-observed 2D NMR spectra (¹H-¹⁵N, ¹H-¹³C, HSQC, HMQC), providing an interactive display of batch processing results for comprehensive analysis.

Affinity Selection Mass Spectrometry (AS-MS)

Simplify and accelerate AS-MS analysis with our comprehensive suite of features that ensure precision and efficiency. Affinity Screen automates data processing and binding assessment, accelerating the comprehension of protein/RNA/DNA-ligand interactions and expediting the transition to hit validation and optimization. No need to sift through irrelevant data. Quickly spot the wells with positive binding to review potential promising leads with ease.

Quantitative Binding Analysis by NMR

Specializing in chemical shift perturbation analysis for fragment-based drug discovery, Mnova Binding processes 2D HSQC spectra, tracks peak movements, computes dissociation constants (Kd’s), and carries out statistical analysis. This tool integrates with third-party software like AFFINImeter for advanced binding isotherm analysis using different models.