Mestrelab Research S.L. and AFFINImeter reach an agreement

Mestrelab Research and Software 4 Science Developments-AFFINImeter have agreed to boost the use of advanced analysis of binding isotherms from 2D-NMR titrations. For this reason, all users interested in purchasing a license for Mnova Binding will benefit from a free annual license of AFFINImeter for Nuclear Magnetic Resonance package.
Mnova Binding is a powerful tool that automatically processes 2D HSQC type of protein-ligand titration spectra, tracks the peak movement and computes the Kd‘s for multiple peaks.

• Intuitive workflow that allows you to analyze CSP titration spectra interactively or fully automatically.
•  Automatic peak movement tracking and measurement of chemical shift perturbations (CSPs), fitting them to the concentrations of ligands to compute Kd.
•  Corrects the automatic peak movement tracking in crowded spectral areas.
•  Provides tools for processing and stacking multiple 2D HSQC spectra. It displays them in different colors.
•  Easy exporting of CSP values for further studies of the ligand-protein binding models.

AFFINImeter for Nuclear Magnetic Resonance allows the advanced analysis of binding isotherms from 2D NMR titrations to measure binding constants (K_A). The binding isotherms are imported directly from the software Mnova and a series of advanced tools are available in AFFINImeter-NMR to get the most out of your NMR data including:

• Global analysis of binding isotherms.
• Analysis with complex binding models
• Advanced algorithms to guarantee convergence avoiding local minima, as well as to assess the parameter uncertainties, the goodness of fit and result reliability.

Instructions to start (PDF)

More info here: Start using AFFINImeter-NMR